South African President Thabo Mbeki will accept a call to resign by the governing African National Congress (ANC), his spokesman has said.
Mukoni Ratshitanga said Mr Mbeki would leave his post once "all constitutional requirements have been met".
It comes days after a High Court judge suggested that Mr Mbeki may have interfered in a corruption case against his rival, ANC leader Jacob Zuma.
Mr Zuma was expected to succeed Mr Mbeki in scheduled elections next year.
Mr Mbeki has called for his cabinet to meet on Sunday.
Parliament is expected to meet in the coming days to formalise the resignation, and is likely to appoint the parliamentary speaker as interim leader.
The decision to call for Mr Mbeki's early resignation was taken at a meeting of the ANC's National Executive Committee (NEC).
 |  [Mr Mbeki] agreed that he is going to participate in the process and the formalities  ANC Secretary General Gwede Mantashe  |
The ANC's Secretary General Gwede Mantashe said the move had followed "a long and difficult discussion".
He said Mr Mbeki, who has ruled for more than a decade, "did not display shock" at the decision and had agreed to participate "in the process and the formalities".
The decision had been taken for "stability and for a peaceful and prosperous South Africa", Mr Mantashe told a news conference.
The ANC secretary general said this was not punishment for Thabo Mbeki, adding that the president would be given the chance to continue his role as mediator in Zimbabwe.
At the same time, ANC cabinet members are being urged to remain in government to ensure continued stability.
Political interference
The BBC's Peter Biles in Pretoria says this dramatic decision will fundamentally change South Africa's political landscape.
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Mr Mbeki fired Jacob Zuma as deputy president in 2005 after his financial adviser was found guilty of soliciting a bribe on his behalf.
But Mr Zuma returned to the political stage to topple his rival as ANC leader in bitterly contested elections last year.
Earlier this month a High Court judge dismissed corruption and other charges against Mr Zuma, saying there was evidence of political interference in the investigation.
In his ruling the judge said it appeared that Mr Mbeki had colluded with prosecutors against Jacob Zuma as part of the "titanic power struggle" within the ANC.
The accusation was strongly denied by Mr Mbeki.
Weakened position
Mr Mbeki, who has devoted his life to the ANC, succeeded Nelson Mandela as the party's president in 1997.
He became leader of South Africa in 1999 and won a second term in 2004.
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